diff --git a/meta-python/recipes-devtools/python3-wxgtk4/python3-wxgtk4_4.2.5.bb b/meta-python/recipes-devtools/python3-wxgtk4/python3-wxgtk4_4.2.5.bb
index a84648266e..9a8952df32 100644
--- a/meta-python/recipes-devtools/python3-wxgtk4/python3-wxgtk4_4.2.5.bb
+++ b/meta-python/recipes-devtools/python3-wxgtk4/python3-wxgtk4_4.2.5.bb
@@ -20,6 +20,14 @@ SRC_URI[sha256sum] = "44e836d1bccd99c38790bb034b6ecf70d9060f6734320560f7c4b0d006

 inherit pypi setuptools3 cython pkgconfig features_check

+# wxPython declares setuptools.build_meta in pyproject.toml, but it cannot be
+# built through pyproject-build: the sdist ships a build.py in its top level
+# directory, which shadows the "build" module pyproject-build itself imports:
+#   from build.__main__ import entrypoint
+#   ModuleNotFoundError: No module named 'build.__main__'; 'build' is not a package
+# Keep driving setup.py directly until upstream stops colliding with that name.
+INSANE_SKIP += "pep517-backend"
+
 REQUIRED_DISTRO_FEATURES = "x11"

 export WX_CONFIG = "'${RECIPE_SYSROOT_NATIVE}${bindir}/wx-config --prefix=${STAGING_EXECPREFIXDIR} --baselib=${baselib}'"