diff --git a/meta-oe/recipes-devtools/nodejs/nodejs_22.16.0.bb b/meta-oe/recipes-devtools/nodejs/nodejs_22.16.0.bb
index 4bc829f140..bf2bae27f1 100644
--- a/meta-oe/recipes-devtools/nodejs/nodejs_22.16.0.bb
+++ b/meta-oe/recipes-devtools/nodejs/nodejs_22.16.0.bb
@@ -47,6 +47,10 @@ CVE_PRODUCT += "node.js"
 # v8 errors out if you have set CCACHE
 CCACHE = ""
 
+# Changing qemu options can incorrectly invalidate sstate, even though it is not used.
+# Exclude it from signature generation.
+BB_HASHCONFIG_IGNORE_VARS:append:class-native = " QEMU_OPTIONS "
+
 def map_nodejs_arch(a, d):
     import re