diff --git a/meta-selftest/conf/multiconfig/muslmc.conf b/meta-selftest/conf/multiconfig/muslmc.conf
new file mode 100644
index 0000000000..043cd1ccc3
--- /dev/null
+++ b/meta-selftest/conf/multiconfig/muslmc.conf
@@ -0,0 +1,2 @@
+TCLIBC = "musl"
+TMPDIR = "${TOPDIR}/tmp-mc-musl"
diff --git a/meta/lib/oeqa/selftest/cases/multiconfig.py b/meta/lib/oeqa/selftest/cases/multiconfig.py
index baae9b456f..83cbd1345d 100644
--- a/meta/lib/oeqa/selftest/cases/multiconfig.py
+++ b/meta/lib/oeqa/selftest/cases/multiconfig.py
@@ -70,3 +70,16 @@ TMPDIR = "${TOPDIR}/tmp-mc-tiny"
 
         result = bitbake('mc:test:multiconfig-test-parse -c showvar')
         self.assertIn('MCTESTVAR=test2', result.output.splitlines())
+
+    def test_multiconfig_inlayer(self):
+        """
+        Test that a multiconfig from meta-selftest works.
+        """
+
+        config = """
+BBMULTICONFIG = "muslmc"
+"""
+        self.write_config(config)
+
+        # Build a core-image-minimal, only dry run needed to check config is present
+        bitbake('mc:muslmc:bash -n')