diff --git a/meta/classes-recipe/python_setuptools_build_meta.bbclass b/meta/classes-recipe/python_setuptools_build_meta.bbclass
index 4c84d1e8d0..046b4ffb74 100644
--- a/meta/classes-recipe/python_setuptools_build_meta.bbclass
+++ b/meta/classes-recipe/python_setuptools_build_meta.bbclass
@@ -7,3 +7,7 @@
 inherit setuptools3-base python_pep517
 
 DEPENDS += "python3-setuptools-native python3-wheel-native"
+
+# This isn't nice, but is the best solutions to ensure clean builds for now.
+# https://github.com/pypa/setuptools/issues/4732
+do_configure[cleandirs] = "${PEP517_SOURCE_PATH}/build"