diff --git a/meta/recipes-core/glib-2.0/glib.inc b/meta/recipes-core/glib-2.0/glib.inc
index 349c33bd33c..7fcfd2bf38e 100644
--- a/meta/recipes-core/glib-2.0/glib.inc
+++ b/meta/recipes-core/glib-2.0/glib.inc
@@ -124,6 +124,8 @@ do_install:append () {
 do_install:append:class-native () {
 	# Link gio-querymodules into ${bindir} as otherwise tools like meson won't find it
         ln -rs ${D}${libexecdir}/gio-querymodules ${D}${bindir}
+	# Remove gdb plugins as we'd never use them for native and they encode system build paths into their location
+	rm ${D}${datadir}/gdb -rf
 }
 
 do_install:append:class-target () {