diff --git a/meta/conf/layer.conf b/meta/conf/layer.conf
index 54fa04e213..5e78bcfeaf 100644
--- a/meta/conf/layer.conf
+++ b/meta/conf/layer.conf
@@ -116,6 +116,13 @@ SSTATE_EXCLUDEDEPS_SYSROOT += "\
     .*->perlcross-native \
     libarchive-native->e2fsprogs-native \
 "
+# Avoid adding dependencies of rpm-sequoia-native as
+# it needs none of its build dependencies to run.
+# It can save significant disk space and speeds up packaging
+# into signed rpms a little.
+SSTATE_EXCLUDEDEPS_SYSROOT += "\
+    rpm-sequoia-native->.* \
+"
 # Nothing needs to depend on libc-initial
 # base-passwd/shadow-sysroot don't need their dependencies
 SSTATE_EXCLUDEDEPS_SYSROOT += "\